宝宝刚出生就16岁

风刀霜剑

　　16年前，29岁的李娟(化名)利用试管婴儿技术成功生下了一名男婴，剩余的18个胚胎被冷冻保存。全面二孩政策正式实施后，她再次来到中山大学附属第一医院生殖医学中心，在医生的帮助下，唤醒了当年的冷冻胚胎并顺利怀孕。最近，46岁的她再度成功顺产分娩一名男婴，母子平安，目前准备出院。据介绍，中山一院从1994年开始就有冷冻胚胎技术，近期就诞生了两例沉睡超过16年的“冰宝宝”。据悉，李娟这例是迄今广东出生“最老”“冰宝宝”。
　　中山一院生殖医学中心徐艳文主任介绍，2000年，身患多囊卵巢综合征的李娟在丈夫的陪同下，来到生殖中心做试管婴儿。幸运的是，他们很快就成功了，并顺利诞下一名健康男婴。时年4月，他们将剩余的18个胚胎冷冻储存起来。
　　全面二孩政策实施后，许多被冷冻的小胚胎被解冻、复苏并植入母体。而这些母亲中，40岁以上的高龄人群越来越多，李娟就是其中一员。


　　产科医生望着刚出生的“幸运宝宝” 图/金羊网记者周巍
　　“我们常说，怀孕最重要的是种子和土壤。这名产妇的种子是16年前保存的胚胎，当时是程序化慢速冷冻技术，这对于胚胎的存活是一大考验。16年后，产妇本身也有内膜息肉，需要宫腔镜去除;还有子宫肌瘤，考虑到冷冻胚胎植入的原因，我们先没有处理肌瘤。”徐艳文告诉记者。
　　2016年5月，在医生的帮助下，解冻了9个沉睡的冷冻胚胎，只有一个退化，其余8个在体外培育三天后全部苏醒。医生择优选择了其中一个胚胎植入李娟的子宫，命运之神再次眷顾，又成功了!李娟顺利怀孕，剩余的胚胎在体外养成了囊胚后再次被冷冻储存。由于李娟此时已经46岁了，身体机能大不如前，而且她本身还有地中海贫血、妊娠期糖尿病等疾病，所以整个孕期她过得并不轻松。历经十几次产检的密切监测，今年2月初，怀孕38周+的她顺利诞下了一名近8斤的男婴。
　　资料图
　　冷冻16年，冰宝宝的健康状况会不会比新鲜胚胎要差呢?对此，徐艳文主任表示，尽管胚胎需要复苏过程，但用李娟29岁时冷冻的胚胎肯定比46岁时取卵做试管婴儿更好。据介绍，随着全面二孩政策实施，选择用辅助生殖技术生二孩的高龄女性越来越多，中山一院去年40岁以上要求助孕的女性已经近千人。
　　中山一院妇产科王子莲主任表示，并不鼓励40岁以上的女性取卵做试管婴儿，因为后续的孕育过程风险会大大增加，“女性年龄越大，胚胎异常比例和畸形胎率也就越高，孕期各种合并症的发生概率也高很多。”王子莲表示，就李娟这个个案来看，解冻胚胎生出来的宝宝，应该是更接近自然的，“46岁取卵做试管婴儿，活产率5%都不到。”可她也指出，如今也有50岁以上的女性来咨询二孩生育，“这种我们会在门诊时就将她们劝退。”
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